The secret origin of HIV #Beekhaybee

When HIV and AIDS appeared they seemed to come from
nowhere, but genetics has told us when and where the
virus first entered the human population

It is easy to see why AIDS seemed so mysterious and
frightening when US medics first encountered it 35 years
ago. The condition robbed young, healthy people of their
strong immune system, leaving them weak and vulnerable.
And it seemed to come out of nowhere.
Today we know much more how and why HIV – the virus
that leads to AIDS – has become a global pandemic.
Unsurprisingly, sex workers unwittingly played a part. But
no less important were the roles of trade, the collapse of
colonialism, and 20th Century sociopolitical reform.
HIV did not really appear out of nowhere, of course. It
probably began as a virus affecting monkeys and apes in
west central Africa.
From there it jumped species into humans on several
occasions, perhaps because people ate infected bushmeat.
Some people carry a version of HIV closely related to that
seen in sooty mangabey monkeys , for instance. But HIV
that came from monkeys has not become a global
problem.
It seems that this form of HIV simply took
advantage of events
We are more closely related to apes, like gorillas and
chimpanzees, than we are to monkeys. But even when HIV
has passed into human populations from these apes, it
has not necessarily turned into a widespread health issue.
HIV originating from apes typically belongs to a type of
virus called HIV-1. One is called HIV-1 group O, and
human cases are largely confined to west Africa .
In fact, only one form of HIV has spread far and wide after
jumping to humans. This version, which probably
originated from chimpanzees, is called HIV-1 group M (for
“major”). More than 90% of HIV infections belong in group
M. Which raises an obvious question: what’s so special
about HIV-1 group M?
A study published in 2014 suggests a surprising answer:
there might be nothing particularly special about group M.
It is not especially infectious, as you might expect.
Instead, it seems that this form of HIV simply took
advantage of events. “Ecological rather than evolutionary
factors drove its rapid spread,” says Nuno Faria at the
University of Oxford in the UK.
Faria and his colleagues built a family tree of HIV, by
looking at a diverse array of HIV genomes collected from
about 800 infected people from central Africa.
The very first person to be infected with HIV-1
group M probably picked up the virus in the 1920s
Genomes pick up new mutations at a fairly steady rate, so
by comparing two genome sequences and counting the
differences they could work out when the two last shared a
common ancestor. This technique is widely used, for
example to establish that our common ancestor with
chimpanzees lived at least 7 million years ago .
“RNA viruses such as HIV evolve approximately 1 million
times faster than human DNA,” says Faria. This means the
HIV “molecular clock” ticks very fast indeed.
It ticks so fast, Faria and his colleagues found that the HIV
genomes all shared a common ancestor that existed no
more than 100 years ago. The HIV-1 group M pandemic
probably first began in the 1920s.
Then the team went further. Because they knew where
each of the HIV samples had been collected, they could
place the origin of the pandemic in a specific city:
Kinshasa, now the capital of the Democratic Republic of
Congo.
At this point, the researchers changed tack. They turned to
historical records to work out why HIV infections in an
African city in the 1920s could ultimately spark a
pandemic.
A likely sequence of events quickly became obvious.
Everything was in place for an explosion in
infection rates in the 1960s
In the 1920s, DR Congo was a Belgian colony and
Kinshasa – then known as Leopoldville – had just been
made the capital. The city became a very attractive
destination for young working men seeking their fortunes,
and for sex workers only too willing to help them spend
their earnings. The virus spread quickly through the
population.
It did not remain confined to the city. The researchers
discovered that the capital of the Belgian Congo was, in the
1920s, one of the best connected cities in Africa. Taking
full advantage of an extensive rail network used by
hundreds of thousands of people each year, the virus
spread to cities 900 miles (1500km) away in just 20 years.
Everything was in place for an explosion in infection rates
in the 1960s.
The beginning of that decade brought another change.
The story of the spread of HIV is not over yet
Belgian Congo gained its independence, and became an
attractive source of employment to French speakers
elsewhere in the world, including Haiti. When these young
Haitians returned home a few years later they took a
particular form of HIV-1 group M, called “subtype B”, to the
western side of the Atlantic.
It arrived in the US in the 1970s, just as sexual liberation
and homophobic attitudes were leading to concentrations
of gay men in cosmopolitan cities like New York and San
Francisco . Once more, HIV took advantage of the
sociopolitical situation to spread quickly through the US
and Europe.
“There is no reason to believe that other subtypes would
not have spread as quickly as subtype B, given similar
ecological circumstances,” says Faria.
The story of the spread of HIV is not over yet.
For instance, in 2015 there was an outbreak in the US state
of Indiana , associated with drug injecting.
The US Centers for Disease Control and Prevention has
been analyzing the HIV genome sequences and data about
location and time of infection, says Yonatan Grad at the
Harvard School of Public Health in Boston, Massachusetts.
“These data help to understand the extent of the outbreak,
and will further help to understand when public health
interventions have worked.”
This approach can work for other pathogens. In 2014, Grad
and his colleague Marc Lipsitch published an investigation
into the spread of drug-resistant gonorrhoea across the
US .
“Because we had representative sequences from
individuals in different cities at different times and with
different sexual orientations, we could show the spread
was from the west of the country to the east,” says
Lipsitch.
What’s more, they could confirm that the drug-resistant
form of gonorrhoea appeared to have circulated
predominantly in men who have sex with men. That could
prompt increased screening in these at-risk populations,
in an effort to reduce further spread.
In other words, there is real power to studying pathogens
like HIV and gonorrhoea through the prism of human
society.

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